“Seeking and using the evidence in clinical practice”

Oxford–Thessaloniki Diabetes Forum is a 3-day course for young diabetologists, organised by the Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM) and the Second Medical Department of the Aristotle University Thessaloniki. Faculty comprises of experts in the field from OCDEM, McMaster University Canada and universities across Greece (Athens, Thessaloniki and Alexandrupoli).

The content focuses on the practice of evidence accumulation, retrieval and establishing appraisal techniques for research and clinical practice in diabetes. This course aims to provide an opportunity for young enthusiastic diabetologists to get a taste of research and clinical practice in Centres of Excellence. Working together, participants will learn how simple evidence-based medicine and research techniques can be applied to improve diabetes care. Research experience is not required.

The course is under the auspices of the Medical School, Aristotle University Thessaloniki, Harris Manchester Medical Academy, Hellenic Diabetes Association and European Association for the Study of Diabetes. The course is supported by an unrestricted educational grant from Novo Nordisk.



DAY 1: Wednesday, 11th May 2011
09:00 - 09:30 Registration & welcome

What is evidence-based medicine / practice?

Speaker: A. Tsapas
09:30 – 10:00

Asking well formulated questions – PICO

Speaker: N. Papanas
10:00 – 10:30

Searching basics – Finding the evidence – Pubmed

Speaker: N. Papanas
10:30 – 11:00
11:00 - 11:30 Coffee / Tea

Rapid critical appraisal

Speaker: D. Goulis
11:30 – 12:15

Trials, trials, trials

12:15 – 13:30
13:30 - 14:30 Lunch break

Systematic reviews – Metaanalysis – Cochrane

Speaker: G. Leontiadis
14:30 – 15:15

Taking action – Applying the evidence

Speaker: K. Makrylakis
15:15 – 15:45
15:45 - 16:15 Coffee / Tea

Hands on – What can you find?

16:15 – 18:00
DAY 2: Thursday, 12th May 2011

Numbers, numbers, numbers

Speaker: D. Matthews
08:45 – 09:30

Stats in small doses

Speaker: J. Levy
09:30 – 10:30
10:30 - 11:00 Coffee / Tea

Using the literature

Speaker: A. Clark
11:00 – 12:00
Research project (in silico) - Workshop

Introduction to Workshop and Experimental Scenarios

Speakers: J. Levy
12:00 – 12:15

Hypothesis formulation & project design

Speaker: D. Matthews & J. Levy
12:15 – 13:00
13:00 - 14:00 Lunch break

Data analysis

Speakers: A. Clark, J. Levy, D. Matthews
14:00 – 15:30
15:30 - 16:00 Coffee / Tea

Preparation of abstract & slides

Speakers: A. Clark, J. Levy, D. Matthews
16:00 – 17:00


Speakers: A. Clark, J. Levy, D. Matthews
17:00 – 19:00
DAY 3: Friday, 13th May 2011

This house believes that... – Debate

Diabetes diagnosis: glucose or HbA1c? D. Goulis vs. K. Makrylakis
09:00 – 10:00

What does an editor look for?

Speaker: D. Mikhailidis
10:00 – 10:45
10:45 - 11:15 Coffee / Tea

Hypoglycaemia in type 2 diabetes

Speaker: J. Levy
11:15 – 11:45

ADA/EASD guidelines: critical appraisal

Speaker: D. Matthews
11:45 – 12:30

Evidence-based practice in diabetes

Speaker: A. Tsapas
12:30 – 13:00


Anne Clark

Anne Clark is a Principal Investigator in Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) with a specialty in the structure and function of pancreatic islets in Type 2 diabetes.

In 1987, with the late Professor Robert Turner, her team identified the peptide component of amyloid deposits (islet amyloid polypeptide, amylin) that form in the pancreatic islets in Type 2 diabetes. Her current interests include protein folding and amyloid formation, lipid handling in islets and structure and function of pancreatic islets in health and disease using light and electron microscopy; collaborators include colleagues in UK, Europe, USA, Canada and Australia.

She participates in graduate teaching programmes in UK and Europe, reviews grant applications and manuscripts for scientific journals.

Dimitrios Goulis

Dr. Dimitrios G. Goulis was born in Thessaloniki, Greece. He completed his basic medical training (M.D.) and received his Ph.D. degree from the Aristotle University of Thessaloniki (A.U.Th.). Having a European Union scholarship, he worked for four years at St. Mary’s and Hammersmith Hospitals, London, UK, acquiring the specialty of Endocrinology and Metabolism. During his training in the UK, he worked in the fields of metabolism, reproductive endocrinology and metabolic complications of pregnancy, under the supervision of professors Desmond Johnston, Stephen Franks and Michael de Swiet. In 2004, he was appointed lecturer and in 2009 assistant professor of Reproductive Endocrinology in the First Department of Obstetrics and Gynecology, A.U.Th. (Head: Professor Basil C. Tarlatzis). Dr. Goulis’ main research interests include endocrine complications of pregnancy, Andrology and research methodology. He has published more than 90 full papers in peer-review international journals. Currently he is associate editor of “Human Reproduction” and a member of the executive councils of the European Academy of Andrology and the Hellenic Endocrine Society.

Grigorios Leontiadis

Qualified from Aristotle University of Thessaloniki in 1992 and trained in Gastroenterology in Greece and in the UK. He worked in the UK as a Consultant Gastroenterologist, and in Greece in private practice (Thessaloniki) and as a Lecturer (Democritus University of Thrace). In 2008 he moved to McMaster University, Hamilton, Canada as Assistant Professor in the Department of Medicine.

His research interests include non-variceal upper gastrointestinal bleeding, H. pylori infection and methodology of systematic reviews. He has 29 Medline-indexed publications, Impact Factor 113, Citation Index 660, h-index 11. In 2005 he was selected by the Emerging Leaders Programme as one of the 40 best young GI researchers worldwide. In 2008 he was involved in the development of the Hellenic and the international guidelines on the management of non-variceal upper GI bleeding.

He is the Deputy Coordinating Editor of the Cochrane Database of Systematic Reviews, Upper GI & Pancreatic Diseases Group, Associate Editor of American Journal of Gastroenterology (starting July 2009), Editorial Board member of Annals of Gastroenterology and Alimentary Pharmacology and Therapeutics, and Chair of the American Gastroenterological Association review committee for non-variceal Upper GI bleeding.

Konstantinos Makrilakis

Konstantinos Makrilakis was born in Rethymno, Crete. He graduated from the Athens University Medical School in 1988 and finished his PhD in the same University in 1992. He trained in Internal Medicine in Chicago, USA. He also holds a Master in Public Health Diploma in Epidemiology and Biostatistics from the School of Public Health, University of Illinois at Chicago, USA.

He is currently an Assistant Professor in Internal Medicine of the Athens University Medical School and works in the First Department of Propaedeutic Medicine and Diabetologic Center in Laiko General Hospital. His research interests are focused on diabetes and its complications and more specifically on prediction and prevention of type 2 diabetes and the influence of 24 hour glycemia on diabetic complications. He has published 26 manuscripts in peer-reviewed journals; he serves as a reviewer in 6 international journals; has written chapters in 3 Greek and 5 international books and has participated in 52 international and 46 Greek congresses.

Jonathan Levy

Dr Jonathan Levy is Clinical Director of the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) and is responsible for the delivery of specialist National Health Service diabetes care for Oxfordshire where he is also actively involved in teaching.

He is based in the University of Oxford Nuffield Department of Clinical Medicine and his research interests focus on the pathophysiology and treatment of type 2 diabetes. He is a member of the steering committee of the 4-T (Treat to Target in Type 2 diabetes) trial and a co-author on publications arising from the study. He has published papers on the assessment of β-cell function, insulin resistance in diabetes and on potential treatments for diabetes.

David R. Matthews

David Matthews is Professor of Diabetes Medicine at the University of Oxford, Medical Tutor, at Harris Manchester College, consultant physician and the Chairman of the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), one of the largest combined academic and clinical centres for diabetes and endocrinology in the UK.

His academic research interests include mathematical modelling of insulin resistance. There is a research focus on physiological research into diabetes agents, in particular at the level of the beta-cell involving incretins and sulphonylureas. An ongoing concern about the world pandemic of diabetes resulted in the founding of the Oxford Health Alliance which published its ‘Grand challenges’ in Nature in 2007 (www.3four50.com) and is working towards combating the scourge of the diabetes epidemic in the world. We are establishing an observational link to the Andover Vision project – a UK civic renewal programme.

He is the author of more than 200 publications and is on the editorial boards of several professional journals.

Dimitri P. Mikhailidis

Dimitri P. Mikhailidis is Academic Head, Reader and Honorary Consultant, Department of Clinical Biochemistry, Royal Free Hospital campus, University College London Medical School. He also is a Visiting Professor at Robert Gordon University (Aberdeen, Scotland) and the Medical School of the University of Ioannina, Greece. His clinical interest is vascular disease prevention, and his research interests are dyslipidaemias and thrombosis. He is a former Wellcome Trust fellow. He has 847 entries on MEDLINE and 11,043 citations listed in the ISI index (H-factor = 49). He is editor-in-chief of several journals including Current Medical Research and Opinion, Current Vascular Pharmacology and Expert Opinion on Investigational Drugs Expert (impact factors = 2.5 to 4.2). He is a member of the nucleus group for peripheral arterial disease, European Society of Cardiology. He is the lead for the Prevention Section of the European Society of Vascular Surgery (ESVS) Guidelines for the Management of Carotid Artery Disease.

Nikolaos Papanas

Dr. Nikolaos Papanas was born in Thessaloniki, Greece and studied Medicine at Aristotle University of Thessaloniki. In 2002, he defended his dissertation on the co-existence of peripheral arterial and coronary artery disease in patients with diabetes. Between 2003 and 2008, he worked as Senior Lecturer in Internal Medicine at Democritus University of Thrace, Alexandroupolis, Greece. Since 2008, his current position is Assistant Professor in Internal Medicine at the same university.

He was trained in diabetes and its complications in the Diabetes Centre and the Diabetic Foot Clinic at King’s College Hospital, London, UK. He has published more than 50 papers in peer-reviewed journals. He has also participated with numerous presentations in Greek and European medical congresses and repeatedly been invited reviewer in medical journals.

Apostolos Tsapas

Dr. Apostolos Tsapas was born in Thessaloniki, Greece and studied Medicine at Aristotle University of Thessaloniki. He is currently Assistant Professor of Medicine and Principal Investigator in the Diabetes Clinic at the Second Medical Department of the Aristotle University Thessaloniki in Ippokratio Hospital. He is a Senior Research Fellow in the Medical Academy within Harris Manchester College, Oxford UK. He was trained in diabetes in the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) with Prof. Dr Matthews, with a fellowship from the European Foundation for the Study of Diabetes (Albert Renold Fellowship – EFSD). This was the starting point for the setup of Oxford Thessaloniki Diabetes Forum.

His main research interests focus on research methodology, evidence-based medicine/diabetology, translational research/knowledge translation and physiological studies in diabetes. He is currently studying for an MSc in Evidence-Βased Health Care in the Centre for Evidence-Based Medicine, Oxford UK.


The cooperation between Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) and the Metabolic Diseases Unit, Second Medical Department, Aristotle University Thessaloniki (Assoc Prof Konstantinos Paletas) began in 2007. Starting point was Dr Tsapas’ sabbatical with Prof DR Matthews in OCDEM, supported by an EFSD (European Foundation for the Study of Diabetes – Albert Renold) fellowship. This cooperation was supported both by Prof Maria Raptopoulou – Gigi (Head, Second Medical Department) and Prof Nikolaos Dombros (Dean, Medical School).

Aim is the setup of educational and research links between centres of excellence, to support postgraduate education, and career development of academic personnel.

Oxford – Thessaloniki Forum is the realisation of this link. We do hope that this course, which focuses on the interaction of young diabetologists with experienced researchers, will be successful, and will lead to further common educational and research links.


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Oxford-Thessaloniki Diabetes Forum. Sponsored by Novo_Nordisk2

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